Definitely, man! What's the occasion? Where are you staying? What kind of games are you gonna play? Just tournaments, or will you try your hand at some cash games?
My favorite cash game is the Venetian $1/$2. It seems pretty easy, the money is good, and the room is amazing. Not to mention the Grand Lux cafe is nearby, which I make sure I hit every time I'm in Vegas (twice, even).
Good luck, but more importantly: play well!